First difference was how different protection was from the two civilizations. Mesopotamia did not have much protection from invaders and was more open to attacks. Mesopotamia was built in the fertile area between Tigris and Euphrates River. The deserts and the rivers did not keep out invaders. Mesopotamians constantly fought off attackers. In Egypt, the Nile River would distance itself from would be invaders as Egypt was built on both the sides of the River Nile. Egypt rarely faced such threats. As a result, Egyptian civilization grew and prospered.
In conclusion, the geographical features of Egypt and Mesopotamia vary in many ways. They both thrived due to having long rivers across the land and even though the floods caused damage it produced rich, fertile soil for planting. These two civilizations shaped the formation of human communities.